1,1-Dimethylhydrazine → 5-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid N',N'-dimethyl-hydrazide

Participants

Reaction Steps

As described for example 1b, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (110 mg, 0.32 mmol), instead of 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester, was converted, using N,N-dimethylhydrazine instead of morpholine, to the title compound (114 mg, 96%) which was obtained as a white foam. MS: m/e=374.2 [M+H]+.

Provenance & Evidence