HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Aminopiperidine → 5-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid piperidin-1-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Aminopiperidine | HCID 16658 | — |
| Reactant | HCID 66643823 | HCID 66643823 | — |
| Product | 5-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid piperidin-1-ylamide | HCID 59568395 | 52% |
Reaction Steps
As described for example 48c, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.29 mmol) was converted, using 1-aminopiperidine instead of N,N-dimethylhydrazine, to the title compound (62 mg, 52%) which was obtained as a colorless oil. MS: m/e=414.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-458a70bb57aa48d181d9e8f56c767ff2 |
| Source note | uspto-grants-2012_04 |