Ethanamine, 2,2,2-trifluoro- → 5-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

Participants

Reaction Steps

As described for example 55, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (100 mg, 0.3 mmol) was converted, using 2,2,2-trifluoroethylamine instead of 2-amino-2-methyl-1-propanol, to the title compound (112 mg, 90%) which was obtained as a white solid. MS: m/e=413.2 [M+H]+.

Provenance & Evidence