1-Methyl-3-aminopyrazole → HCID 59568421, compound

HRID 1695401Notes

Reaction equation

HRID 1695401 reaction equation
C[O:2][C:3]([C:5]1[N:6]([CH3:25])[N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)=[N:14][O:15][C:16]=2[CH3:17])[CH:9]=1)=O.[CH3:26][N:27]1[CH:31]=[CH:30][C:29]([NH2:32])=[N:28]1>>[CH3:26][N:27]1[CH:31]=[CH:30][C:29]([NH:32][C:3]([C:5]2[N:6]([CH3:25])[N:7]=[C:8]([O:10][CH2:11][C:12]3[C:13]([C:18]4[CH:19]=[CH:20][C:21]([F:24])=[CH:22][CH:23]=4)=[N:14][O:15][C:16]=3[CH3:17])[CH:9]=2)=[O:2])=[N:28]1

Participants

3

Reactant 2

HCID 1372541-Methyl-3-aminopyrazoleHCID 66643823HCID 66643823, compound

Product 1

HCID 59568421HCID 59568421, compoundYield 48%

Procedure

As described for example 48c, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.29 mmol) was converted, using 1-methyl-1H-pyrazol-3-ylamine instead of N,N-dimethylhydrazine, to the title compound (58 mg, 48%) which was obtained as a yellow gum. MS: m/e=411.2 [M+H]+.

Sources & evidence

ORD record
ord-e596ae12766443cb9a1ca363d70f4ae3
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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