N-(2-aminoethyl)acetamide → HCID 59568467, compound

HRID 1695402Notes

Reaction equation

HRID 1695402 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([C:21]([OH:23])=O)[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[C:25]([NH:28][CH2:29][CH2:30][NH2:31])(=[O:27])[CH3:26]>>[C:25]([NH:28][CH2:29][CH2:30][NH:31][C:21]([C:17]1[N:18]([CH3:20])[N:19]=[C:15]([O:14][CH2:13][C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[N:9][O:10][C:11]=2[CH3:24])[CH:16]=1)=[O:23])(=[O:27])[CH3:26]

Participants

3

Reactant 2

HCID 66082N-(2-aminoethyl)acetamideHCID 66643617HCID 66643617, compound

Product 1

HCID 59568467HCID 59568467, compoundYield 56%

Procedure

As described for example 55, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (100 mg, 0.3 mmol) was converted, using N-acetylethylendiamine instead of 2-amino-2-methyl-1-propanol, to the title compound (70 mg, 56%) which was obtained as a white solid. MS: m/e=414.1 [M−H]−.

Sources & evidence

ORD record
ord-cb050534935f4009aa013f5450f7624d
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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