2-Amino-1-butanol → HCID 59568414, compound

HRID 1695405Notes

Reaction equation

HRID 1695405 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][O:14][C:15]3[CH:16]=[C:17]([C:21]([OH:23])=O)[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[NH2:25][CH:26]([CH2:29][CH3:30])[CH2:27][OH:28]>>[OH:28][CH2:27][CH:26]([NH:25][C:21]([C:17]1[N:18]([CH3:20])[N:19]=[C:15]([O:14][CH2:13][C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[N:9][O:10][C:11]=2[CH3:24])[CH:16]=1)=[O:23])[CH2:29][CH3:30]

Participants

3

Reactant 2

HCID 221292-Amino-1-butanolHCID 66643617HCID 66643617, compound

Product 1

HCID 59568414HCID 59568414, compoundYield 63%

Procedure

As described for example 55, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (200 mg, 0.6 mmol) was converted, using rac-2-amino-1-butanol instead of 2-amino-2-methyl-1-propanol, to the title compound (155 mg, 63%) which was obtained as a colorless gum. MS: m/e=403.2 [M+H]+.

Sources & evidence

ORD record
ord-c07f966c199d4932b62dc1ec66c49214
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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