4-Aminotetrahydropyran → 2-Methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid (tetrahydro-pyran-4-yl)-amide

Participants

Reaction Steps

As described for example 78b, 2-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (70 mg, 0.21 mmol) was converted using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (43 mg, 51%) which was obtained as a white solid. MS: m/e=398.2 [M+H]+.

Provenance & Evidence