L-Alaninol → 2-Methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide

Participants

Reaction Steps

As described for example 6, 2-methyl-5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (90 mg, 0.27 mmol), instead of 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester, was converted, using L-alaninol instead of ethanolamine, to the title compound (91 mg, 89%) which was obtained as a colorless oil. MS: m/e=372.2 [M+H]+.

Provenance & Evidence