[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-methanol → 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester

Participants

Reaction Steps

As described for example 17d, [3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-methanol (1.03 g, 4.95 mmol), using 5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester instead of 5-hydroxy-2H-pyrazole-3-carboxylic acid methyl ester, was converted to the title compound (770 mg, 47%) which was obtained as a white solid. MS: m/e=333.2 [M+H]+.

Provenance & Evidence