HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopropanol → Rac-5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2-methyl-2h-pyrazole-3-carboxylic acid (2-hydroxy-1-methyl-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopropanol | HCID 5126 | — |
| Reactant | HCID 66643838 | HCID 66643838 | — |
| Product | Rac-5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2-methyl-2h-pyrazole-3-carboxylic acid (2-hydroxy-1-methyl-ethyl)-amide | HCID 59568446 | 70% |
Reaction Steps
As described for example 85b, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (60 mg, 0.2 mmol), was converted, using DL-2-amino-1-propanol instead of ethanolamine, to the title compound (48 mg, 70%) which was obtained as a colorless oil. MS: m/e=351.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-61b93972b2614cc8b664d32bfbbd779c |
| Source note | uspto-grants-2012_04 |