HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminotetrahydropyran → 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2-methyl-2H-pyrazole-3-carboxylic acid (tetra-hydro-pyran-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | HCID 66643838 | HCID 66643838 | — |
| Product | 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2-methyl-2H-pyrazole-3-carboxylic acid (tetra-hydro-pyran-4-yl)-amide | HCID 59568430 | 95% |
Reaction Steps
As described for example 86, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (60 mg, 0.2 mmol) was converted, using 4-aminotetrahydropyran instead of isopropylamine, to the title compound (70 mg, 95%) which was obtained as a colorless oil. MS: m/e=377.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-779f4cdf712445628103488f13c0b5a2 |
| Source note | uspto-grants-2012_04 |