Isopropylamine → HCID 59568480, compound

HRID 1695431Notes

Reaction equation

C[O:2][C:3]([C:5]1[N:6]([CH3:26])[N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[N:14][O:15][C:16]=2[CH2:17][OH:18])[CH:9]=1)=O.[CH:27]([NH2:30])([CH3:29])[CH3:28]>>[CH:27]([NH:30][C:3]([C:5]1[N:6]([CH3:26])[N:7]=[C:8]([O:10][CH2:11][C:12]2[C:13]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[N:14][O:15][C:16]=2[CH2:17][OH:18])[CH:9]=1)=[O:2])([CH3:29])[CH3:28]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 66643735HCID 66643735, compound

Product 1

HCID 59568480HCID 59568480, compoundYield 56%

Procedure

As described for example 91h, 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (150 mg, 0.42 mmol) was converted, using isopropylamine instead of 4-aminotetrahydropyran, to the title compound (90 mg, 56%) which was obtained as a white solid. MS: m/e=387.0 [M−H]−.

Sources & evidence

ORD record: ord-fa1f041b8e9349c68674a0f26f7874ae
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163728B2

Reaction notes

Loading…