Hydrochloric Acid → 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid

Participants

Reaction Steps

To 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (250 mg, 0.69 mmol) in THF (1.17 mL), methanol (391 μL) and water (1.17 mL) was added lithium hydroxide (33.8 mg, 1.4 mmol). The reaction mixture was stirred for 2 h at room temperature. Addition of aqueous hydrochloride solution (1 N, 25 mL) and extraction with ethyl acetate yielded the title compound (220 mg, 92%) as a light brown solid. MS: m/e=346.0 [M−H]−.

Provenance & Evidence