反应详情

As described for example 100f, 5-[3-(4-chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.27 mmol) was converted, using 2,2,2-trifluoroethylamine instead of isopropylamine, to the title compound (38 mg, 32%) which was obtained as a white solid. MS: m/e=443.0 [M−H]−.