2,2,3,3,3-Pentafluoropropylamine → 5-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (2,2,3,3,3-pentafluoro-propyl)-amide

Participants

Reaction Steps

As described for example 100f, 5-[3-(4-chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.27 mmol) was converted, using 2,2,3,3,3-pentafluoropropylamine instead of isopropylamine, to the title compound (35 mg, 26%) which was obtained as a white solid. MS: m/e=495.1 [M+H]+.

Provenance & Evidence