1,1,1-Trifluoro-2-propanamine → 5-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2h-pyrazole-3-carboxylic acid ((s)-2,2,2-trifluoro-1-methyl-ethyl)-amide

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Reaction Steps

As described for example 100f, 5-[3-(4-chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.27 mmol) was converted, using L-2,2,2-trifluoro-1-(methyl)ethylamine instead of isopropylamine, to the title compound (21 mg, 17%) which was obtained as a colorless gum. MS: m/e=459.3 [M+H]+.

Provenance & Evidence