3-Amino-3-methyloxetane → 5-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (3-methyl-oxetan-3-yl)-amide

Participants

Reaction Steps

As described for example 107, 5-[3-(4-chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (100 mg, 0.28 mmol) was converted, using 3-methyl-3-oxetanamine instead of 2-amino-2-methyl-1-propanol, to the title compound (39 mg, 32%) which was obtained as a white solid. MS: m/e=433.3 [M+H]+.

Provenance & Evidence