4,4-Difluoropiperidine hydrochloride → {5-[3-(4-Chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazol-3-yl}-(4,4-difluoro-piperidin-1-yl)-methanone

Participants

Reaction Steps

As described for example 107, 5-[3-(4-chloro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (100 mg, 0.28 mmol) was converted, using 4,4-difluoropiperidine hydrochloride instead of 2-amino-2-methyl-1-propanol, to the title compound (87 mg, 67%) which was obtained as a colorless gum. MS: m/e=467.2 [M+H]+.

Provenance & Evidence