2-Propanol, 1-amino-2-methyl- → HCID 49793044, compound

HRID 1695474Notes

Reaction equation

HRID 1695474 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12](/[CH:13]=[CH:14]/[C:15]3[CH:16]=[C:17]([C:21]([OH:23])=O)[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[OH:25][C:26]([CH3:30])([CH3:29])[CH2:27][NH2:28]>>[OH:25][C:26]([CH3:30])([CH3:29])[CH2:27][NH:28][C:21]([C:17]1[N:18]([CH3:20])[N:19]=[C:15](/[CH:14]=[CH:13]/[C:12]2[C:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)=[N:9][O:10][C:11]=2[CH3:24])[CH:16]=1)=[O:23]

Participants

3

Reactant 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 66643882HCID 66643882, compound

Product 1

HCID 49793044HCID 49793044, compoundYield 28%

Procedure

As described for example 122, 5-{(E)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2-methyl-2H-pyrazole-3-carboxylic acid was converted, using 2-hydroxy-2-methylpropylamine instead of isopropylamine, to the title compound (9.4 mg, 28%) which was obtained as a white solid. MS: m/e=399.2 [M+H]+.

Sources & evidence

ORD record
ord-e2c0a8e73fb447b0a4afb80870ed0b07
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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