Morpholine → HCID 49793067, compound

HRID 1695478Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12](/[CH:13]=[CH:14]/[C:15]3[CH:16]=[C:17]([C:21](O)=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12](/[CH:13]=[CH:14]/[C:15]3[CH:16]=[C:17]([C:21]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 8083Morpholine

HCID 66643882HCID 66643882, compound

Product 1

HCID 49793067HCID 49793067, compoundYield 25%

Procedure

As described for example 122, 5-{(E)-2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-vinyl}-2-methyl-2H-pyrazole-3-carboxylic acid was converted, using morpholine instead of isopropylamine, to the title compound (8.3 mg, 25%) which was obtained as a white solid. MS: m/e=397.2 [M+H]+.

Sources & evidence

ORD record: ord-493b2514a2e6404fb8e417c85e6ade7d
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163728B2

Reaction notes

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