3-Amino-3-methyloxetane → HCID 59568465, compound

HRID 1695492Notes

Reaction equation

HRID 1695492 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:16]=[C:17]([C:21]([OH:23])=O)[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[CH3:25][C:26]1([NH2:30])[CH2:29][O:28][CH2:27]1>>[CH3:25][C:26]1([NH:30][C:21]([C:17]2[N:18]([CH3:20])[N:19]=[C:15]([NH:14][CH2:13][C:12]3[C:8]([C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)=[N:9][O:10][C:11]=3[CH3:24])[CH:16]=2)=[O:23])[CH2:29][O:28][CH2:27]1

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 66643816HCID 66643816, compound

Product 1

HCID 59568465HCID 59568465, compoundYield 28%

Procedure

As described for example 144, 5-{[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid was converted, using 3-methyl-oxetan-3-yl-amine instead of 2-hydroxy-2-methylpropylamine, to the title compound (17 mg, 28%) which was obtained as a white solid. MS: m/e=400.3 [M+H]+.

Sources & evidence

ORD record
ord-22b9ed870ebb45eba7150b4ed87701f1
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

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