Isopropylamine → HCID 59568441, compound

HRID 1695494Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:16]=[C:17]([C:21](O)=[O:22])[N:18]([CH3:20])[N:19]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[CH:4][CH:3]=1.[CH:25]([NH2:28])([CH3:27])[CH3:26]>>[CH:25]([NH:28][C:21]([C:17]1[N:18]([CH3:20])[N:19]=[C:15]([NH:14][CH2:13][C:12]2[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[N:9][O:10][C:11]=2[CH3:24])[CH:16]=1)=[O:22])([CH3:27])[CH3:26]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 66643816HCID 66643816, compound

Product 1

HCID 59568441HCID 59568441, compoundYield 21%

Procedure

As described for example 144, 5-{[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-amino}-2-methyl-2H-pyrazole-3-carboxylic acid was converted, using isopropylamine instead of 2-hydroxy-2-methylpropylamine, to the title compound (15 mg, 21%) which was obtained as a white solid. MS: m/e=372.2 [M+H]+.

Sources & evidence

ORD record: ord-68a12964d81c4d3bb540e48942a8c5ff
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163728B2

Reaction notes

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