Isopropylamine → HCID 59568457, compound

Participants

Reaction Steps

To a solution of 1-methyl-3-((5-methyl-3-(pyridin-2-yl)isoxazol-4-yl)methylamino)-1H-pyrazole-5-carboxylic acid (80 mg, 255 μmol) in DMF (3 mL) were added TBTU (91 mg, 281 μmol) and N,N-diisopropyl ethyl amine (217 μL, 1.28 mmol) followed by isopropylamine (24 μL, 281 μmol). The mixture was stirred at RT for 1 h, then evaporated. The residue was purified by flash-chromatography over NH2 silica gel using gradient EtOAc/heptane 10-70% to afford the title compound (75 mg, 83%) as a white solid. MS: m/e=355.2 [M+H]+.

Provenance & Evidence