3-Amino-3-methyloxetane → HCID 59568478, compound

HRID 1695510Notes

Reaction equation

HRID 1695510 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:19]=[C:18]([C:20]([OH:22])=O)[N:17]([CH3:23])[N:16]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[N:6][CH:7]=1.[CH3:25][C:26]1([NH2:30])[CH2:29][O:28][CH2:27]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:12]([CH2:13][NH:14][C:15]3[CH:19]=[C:18]([C:20]([NH:30][C:26]4([CH3:25])[CH2:29][O:28][CH2:27]4)=[O:22])[N:17]([CH3:23])[N:16]=3)=[C:11]([CH3:24])[O:10][N:9]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 468357253-Amino-3-methyloxetaneHCID 66646190HCID 66646190, compound

Product 1

HCID 59568478HCID 59568478, compoundYield 81%

Procedure

As described for example 163c, 3-((3-(5-fluoropyridin-2-yl)-5-methylisoxazol-4-yl)methylamino)-1-methyl-1H-pyrazole-5-carboxylic acid (92 mg, 0.28 mol) was converted, using 3-methyl-3-oxetanamine instead of isopropylamine, to the title compound (90 mg, 81%) which was obtained as a white solid. MS: m/e=401.3 [M+H]+.

Sources & evidence

ORD record
ord-1b76589b0e3f409480c7f4526d44879b
Source dataset
uspto-grants-2012_04
Patent number
US08163728B2

Reaction notes

Loading…