2-Bromo-1,3-thiazole-4-carboxylic acid → N-[2-(aminocarbonyl)-5-methylphenyl]-2-bromo-4-thiazolecarboxamide

HRID 1695519노트

반응식

HRID 1695519 반응식
[Br:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([OH:9])=O)[N:6]=1.[NH2:10][C:11]1[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:12]=1[C:13]([NH2:15])=[O:14]>>[NH2:15][C:13]([C:12]1[CH:16]=[CH:17][C:18]([CH3:20])=[CH:19][C:11]=1[NH:10][C:7]([C:5]1[N:6]=[C:2]([Br:1])[S:3][CH:4]=1)=[O:9])=[O:14]

참가 물질

3

반응물 2

HCID 27632092-Bromo-1,3-thiazole-4-carboxylic acidHCID 28014742-Amino-4-methylbenzamide

생성물 1

HCID 57737845N-[2-(aminocarbonyl)-5-methylphenyl]-2-bromo-4-thiazolecarboxamide

실험 절차

2-Bromo-4-thiazolecarboxylic acid and 2-amino-4-methylbenzamide are reacted in analogy to the synthesis of intermediate V.1 to give N-[2-(aminocarbonyl)-5-methylphenyl]-2-bromo-4-thiazolecarboxamide (intermediate V.2).

출처 및 근거

ORD 기록
ord-8f48046ed9aa4bac83bd9cd036bbb369
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163739B2

반응 노트

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