Hydrochloric Acid → HCID 57965497, compound

Participants

Reaction Steps

In a 50 mL round-bottomed flask was dissolved (11β,16α)-21-(Acetyloxy)-11,17-dihydroxy-6,16-dimethyl-2′-phenyl-2′H-pregna-2,4,6-trieno[3,2-c]pyrazol-20-one (also known as Cortivazol) (0.1 g, 0.19 mmol) in MeOH (10 mL) to give a colorless solution. 1M sodium hydroxide (1.2 mL, 1.20 mmol) was added, and the mixture was stirred in an open flask overnight. The solution was acidified by the addition of 1M HCl (1.3 ml), MeOH was removed in vacuo after which the product precipitated as a white solid which was filtered, washed with water and dried in air on the sinter to give 85 mg of the desired product as a white solid. APCI-MS m/z: 475 [MH+].

Provenance & Evidence