HCID 137252519, compound → HCID 44184979, compound

Participants

Reaction Steps

Work in an autoclave as in Stage 3 in Example 5, starting from 449 mg of equimolecular mixture of the Z and E isomers of 4-(1H-imidazol-2-yl)-fluoren-9-one oxime, obtained in the preceding stage, in a mixture of 25 mL of ethanol and 25 mL of tetrahydrofuran, in the presence of Raney nickel, under an initial hydrogen pressure of 1 bar, at 60° C. for 3 hours. After filtration of the catalyst on Celite, concentration of the filtrate at reduced pressure and purification by making into a paste with diisopropyl oxide, we obtain 367 mg of 4-(1H-imidazol-2-yl)-9H-fluorene-9(R,S)-amine, in the form of a white powder, with the following characteristics:

Provenance & Evidence