HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-(5-Acetyl-indan-2-YL)-4-fluoro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | Ave-9488 | HCID 10131276 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | N-(5-Acetyl-indan-2-YL)-4-fluoro-benzamide | HCID 21920974 | — |
Reaction Steps
2.87 g (21.6 mmol) aluminum trichloride were suspended in 10 ml 1,2-dichloroethane, 500 mg (4.9 mmol) acetic anhydride and 1.0 g N-(indan-2-yl)-4-fluoro-benzamide added, and the whole was stirred for 2 h at RT. The resulting mixture was poured onto ice water/HCl, extracted with dichloromethane, the organic phase was dried with Na2SO4 and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163751B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-51f2b73e807941b2aa4986a6d5391e7e |
| Source note | uspto-grants-2012_04 |