HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1695581Generated: November 2, 2026
Hydroxyamine hydrochloride → 4-Methoxy-benzofuran-3-one oxime
https://huagongshe.com/reaction/1695581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 4-Methoxybenzofuran-3(2H)-one | HCID 639146 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Methoxy-benzofuran-3-one oxime | HCID 86634184 | 271.6% |
Reaction Steps
A mixture of 4-methoxy-benzofuran-3-one (CAS 7169-35-9) (30 g, 183 mmol; HPLC 1.241 min), sodium acetate (30.9 g, 375 mmol) and hydroxylamine hydrochloride (5.14 g, 57 mmol) in ethanol (310 ml) was refluxed for 4 h. Cooled to 23° C., filtered the precipitate off, washed with aqueous ethanol and dried in high vacuum to give the title compound as a light red solid (27.74 g, 88%; HPLC 1.448 min); MS (ISP) m/e=180.2 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163740B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-c992812bcb944e168b2076045bc136d7 |
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| Source note | uspto-grants-2012_04 |
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