1-Isopropylpiperazine → HCID 178488346, compound

HRID 1695589Notes

Reaction equation

Cl[CH2:2][C:3]([NH:5][C:6]1[CH:27]=[CH:26][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:19]4[C:20]([O:24][CH3:25])=[CH:21][CH:22]=[CH:23][C:18]=4[O:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[CH:28]([N:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)([CH3:30])[CH3:29]>>[CH:28]([N:31]1[CH2:36][CH2:35][N:34]([CH2:2][C:3]([NH:5][C:6]2[CH:27]=[CH:26][C:9]3[N:10]=[C:11]([NH:14][CH:15]4[C:19]5[C:20]([O:24][CH3:25])=[CH:21][CH:22]=[CH:23][C:18]=5[O:17][CH2:16]4)[O:12][CH2:13][C:8]=3[CH:7]=2)=[O:4])[CH2:33][CH2:32]1)([CH3:30])[CH3:29]

Participants

Reactant 2

HCID 780131-Isopropylpiperazine

HCID 178488343HCID 178488343, compound

Product 1

HCID 178488346HCID 178488346, compoundYield 73%

Procedure

Prepared from rac-2-chloro-N-[2-(4-methoxy-2,3-dihydro-benzofuran-3-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 8) (50 mg, 0.129 mmol) and 1-(isopropyl)piperazine (330 mg, 2.578 mmol) according to the procedure described for Example 3 step B (here the reaction was sonicated for 2 min, which already lead to complete conversion). Obtained the title compound as a white solid (45 mg, 73%), MS (ISP) m/e=480.3 [(M+H)+].

Workup

customwas sonicated for 2 min

Sources & evidence

ORD record: ord-3c14c03c28424bdbabd437af059171de
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163740B2

Reaction notes

Loading…