Ethyl Acetate → HCID 178496377, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of rac-N2-(7-methoxy-indan-1-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 10) (100 mg, 0.321 mmol) in ethyl acetate (5 ml) and sat. sodium hydrogen carbonate-sol. at 0° C. was added methoxyacetyl chloride (35 ul, 0.385 mmol) and the mixture was stirred at 23° C. for 16 h. Diluted with ethyl acetate, washed with water, dried the organic layer over sodium sulfate. After filtration, the solvent was removed in vacuum and the crude product was triturated with diethyl ether to give the title compound as a white solid (90 mg, 73%), MS (ISP) m/e=384.2 [(M+H)+].

Provenance & Evidence