Morpholine → HCID 178521233, compound

HRID 1695605Notes

Reaction equation

HRID 1695605 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][C@H:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[C@H:15]1([NH:14][C:11]2[O:12][CH2:13][C:8]3[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)[CH:25]=[CH:24][C:9]=3[N:10]=2)[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 178520800HCID 178520800, compound

Product 1

HCID 178521233HCID 178521233, compoundYield 49.3%

Procedure

Prepared from 2-chloro-N-[2-((R)-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 3 step A) (355 mg, 0.998 mmol) and morpholine (1.3 ml, 15 mmol) according to the procedure described for Example 3 step B. Obtained the title compound as a white foam (200 mg, 49%), MS (ISP) m/e=407.3 [(M+H)+].

Sources & evidence

ORD record
ord-73df67bc1652499aa3f5a3db4ba96dc5
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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