Chloroacetyl chloride → HCID 178520798, compound

Participants

Reaction Steps

Prepared from rac-N2-(6-fluoro-2,3-dihydro-benzofuran-3-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 34) (748 mg, 2.5 mmol, HPLC 0.641 min) and chloroacetyl chloride (0.21 ml, 2.625 mmol) according to the procedure described for Example 3 step A. Obtained the title compound as a white solid (250 mg, 27%, HPLC 1.056 min), MS (ISP) m/e=376.1 [(M+H)+] and 378 [(M+2+H)+].

Provenance & Evidence