2-Propanol, 1-amino-2-methyl- → HCID 178459315, compound

HRID 1695613Notes

Reaction equation

HRID 1695613 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:26]=[CH:25][C:9]2[N:10]=[C:11]([NH:14][CH:15]3[C:19]4[CH:20]=[CH:21][C:22]([F:24])=[CH:23][C:18]=4[O:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[NH2:27][CH2:28][C:29]([CH3:32])([OH:31])[CH3:30]>C(#N)C>[F:24][C:22]1[CH:21]=[CH:20][C:19]2[CH:15]([NH:14][C:11]3[O:12][CH2:13][C:8]4[CH:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][NH:27][CH2:28][C:29]([OH:31])([CH3:32])[CH3:30])[CH:26]=[CH:25][C:9]=4[N:10]=3)[CH2:16][O:17][C:18]=2[CH:23]=1

Participants

4

Reactant 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 178520798HCID 178520798, compound

Product 1

HCID 178459315HCID 178459315, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from rac-2-chloro-N-[2-(6-fluoro-2,3-dihydro-benzofuran-3-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 42 step A) (50 mg, 0.133 mmol, HPLC 1.056 min) and 1-amino-2-methyl-propan-2-ol (237 mg, 2.66 mmol) in acetonitrile (3 ml) according to the procedure described for Example 3 step B. Obtained the title compound as a white solid (57 mg, 100%, HPLC 0.473 min 100%), MS (ISP) m/e=429.3 [(M+H)+].

Sources & evidence

ORD record
ord-57c9d0bd89a24368babe0f34731a42f2
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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