Piperidine-1-sulfonyl chloride → HCID 178488359, compound

HRID 1695616Notes

Reaction equation

HRID 1695616 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[O:14][CH2:15][C:16]4[CH:22]=[C:21]([NH2:23])[CH:20]=[CH:19][C:17]=4[N:18]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.[N:24]1([S:30](Cl)(=[O:32])=[O:31])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH3:1][O:2][C:3]1[C:8]2[CH:9]([NH:12][C:13]3[O:14][CH2:15][C:16]4[CH:22]=[C:21]([NH:23][S:30]([N:24]5[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]5)(=[O:32])=[O:31])[CH:20]=[CH:19][C:17]=4[N:18]=3)[CH2:10][O:11][C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 11298344Piperidine-1-sulfonyl chlorideHCID 178488337HCID 178488337, compound

Product 1

HCID 178488359HCID 178488359, compoundYield 48%

Procedure

Prepared from rac-N2-(4-methoxy-2,3-dihydro-benzofuran-3-yl)-4H-benzo[d][1,3]oxazine-2,6-diamine (Example 6) (100 mg, 0.321 mmol) and piperidine-1-sulfonyl chloride (65 mg, 0.353 mmol) according to the procedure described for Example 27. Obtained the title compound as a light red foam (70 mg, 48%), MS (ISP) m/e=459.3 [(M+H)+].

Sources & evidence

ORD record
ord-011c960b3f7a491ea2cacdd5893ad4ce
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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