2-Amino-4-(trifluoromethyl)pyrimidine → HCID 178505423, compound

HRID 1695625Notes

Reaction equation

HRID 1695625 reaction equation
Br[C:2]1[CH:22]=[CH:21][C:5]2[N:6]=[C:7]([NH:10][CH:11]3[C:19]4[C:14](=[CH:15][C:16]([F:20])=[CH:17][CH:18]=4)[CH2:13][CH2:12]3)[O:8][CH2:9][C:4]=2[CH:3]=1.[NH2:23][C:24]1[N:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][N:25]=1>>[F:20][C:16]1[CH:15]=[C:14]2[C:19](=[CH:18][CH:17]=1)[CH:11]([NH:10][C:7]1[O:8][CH2:9][C:4]3[CH:3]=[C:2]([NH:23][C:24]4[N:29]=[C:28]([C:30]([F:33])([F:31])[F:32])[CH:27]=[CH:26][N:25]=4)[CH:22]=[CH:21][C:5]=3[N:6]=1)[CH2:12][CH2:13]2

Participants

3

Reactant 2

HCID 5959152-Amino-4-(trifluoromethyl)pyrimidineHCID 178505421HCID 178505421, compound

Product 1

HCID 178505423HCID 178505423, compoundYield 51%

Procedure

The title compound (113 mg, 51%), yellow foam, MS (ISP): m/e=444.2 (M+H+), was prepared in accordance with the general method of Example 35 from rac-(6-bromo-4H-benzo[d][1,3]oxazin-2-yl)-(5-fluoro-indan-1-yl)-amine (Example 53) (181 mg, 0.5 mmol) and commercially available 2-amino-4-trifluoromethyl-pyrimidine (163 mg, 1.0 mmol).

Sources & evidence

ORD record
ord-1cde3d2da62443d589330469ced6d3a6
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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