Imidazole → HCID 178521199, compound

HRID 1695632Notes

Reaction equation

HRID 1695632 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:25]=[CH:24][C:9]2[N:10]=[C:11]([NH:14][C@H:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH2:17][CH2:16]3)[O:12][CH2:13][C:8]=2[CH:7]=1)=[O:4].[NH:26]1[CH:30]=[CH:29][N:28]=[CH:27]1>C(#N)C>[N:26]1([CH2:2][C:3]([NH:5][C:6]2[CH:25]=[CH:24][C:9]3[N:10]=[C:11]([NH:14][C@H:15]4[C:23]5[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=5)[CH2:17][CH2:16]4)[O:12][CH2:13][C:8]=3[CH:7]=2)=[O:4])[CH:30]=[CH:29][N:28]=[CH:27]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 178520800HCID 178520800, compound

Product 1

HCID 178521199HCID 178521199, compoundYield 73.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared from 2-chloro-N-[2-((R)-indan-1-ylamino)-4H-benzo[d][1,3]oxazin-6-yl]-acetamide (Example 3 step A) (100 mg, 0.281 mmol) and imidazole (96 mg, 1.405 mmol) in acetonitrile (1 ml) according to the procedure described for Example 3 step B. Obtained the title compound as a white solid (80 mg, 73%), MS (ISP) m/e=388.3 [(M+H)+].

Sources & evidence

ORD record
ord-ba6d0b0584154aeda2bf24e7b399bc1c
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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