Cyclopropanecarboxylic acid → HCID 178521734, compound

HRID 1695651Notes

Reaction equation

HRID 1695651 reaction equation
[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:20]1([C:23](O)=[O:24])[CH2:22][CH2:21]1>>[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH:19][C:23]([CH:20]4[CH2:22][CH2:21]4)=[O:24])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 178507250HCID 178507250, compound

Product 1

HCID 178521734HCID 178521734, compoundYield 41.3%

Procedure

Prepared from N2-cycloheptyl-4H-benzo[d][1,3]oxazine-2,6-diamine (example 92) (200 mg, 0.77 mmol) and cyclopropanecarboxylic acid (80 mg, 0.93 mmol) according to the procedure described for example 93. Obtained the title compound as an off-white foam (104 mg, 41%), MS (ISP) m/e=328.4 [(M+H)+].

Sources & evidence

ORD record
ord-c585b15944804a3eab503a8a6c47d681
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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