1,3-Thiazole-2-carbaldehyde → HCID 178420851, compound

HRID 1695654Notes

Reaction equation

HRID 1695654 reaction equation
[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:20]([C:22]1[S:23][CH:24]=[CH:25][N:26]=1)=O>>[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH:19][CH2:20][C:22]4[S:23][CH:24]=[CH:25][N:26]=4)[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 27349031,3-Thiazole-2-carbaldehydeHCID 178507250HCID 178507250, compound

Product 1

HCID 178420851HCID 178420851, compoundYield 39%

Procedure

Prepared from N2-cycloheptyl-4H-benzo[d][1,3]oxazine-2,6-diamine (example 92) (188 mg, 0.73 mmol) and 2-formylthiazole (90 mg, 0.80 mmol) according to the procedure described for example 88. Obtained the title compound as a yellow foam (101 mg, 39%), MS (ISP) m/e=357.3 [(M+H)+].

Sources & evidence

ORD record
ord-e2debb3ad4ce466985fa42de4ebbf2d9
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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