1H-imidazole-2-carbaldehyde → HCID 178420816, compound

HRID 1695659Notes

Reaction equation

HRID 1695659 reaction equation
[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH2:19])[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:20]([C:22]1[NH:23][CH:24]=[CH:25][N:26]=1)=O>>[CH:1]1([NH:8][C:9]2[O:10][CH2:11][C:12]3[CH:18]=[C:17]([NH:19][CH2:20][C:22]4[NH:23][CH:24]=[CH:25][N:26]=4)[CH:16]=[CH:15][C:13]=3[N:14]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 249551H-imidazole-2-carbaldehydeHCID 178507250HCID 178507250, compound

Product 1

HCID 178420816HCID 178420816, compoundYield 74%

Procedure

Prepared from N2-cycloheptyl-4H-benzo[d][1,3]oxazine-2,6-diamine (example 92) (150 mg, 0.58 mmol) and 2-formylimidazole (67 mg, 0.70 mmol) according to the procedure described for example 88. Obtained the title compound as an off-white foam (145 mg, 74%), MS (ISP) m/e=338.5 [(M−H)+].

Sources & evidence

ORD record
ord-57c50674322a4298942b94ba6aee6d68
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

Loading…