HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Methylpiperazin-1-yl)acetic acid → N-[2-(3-Cyclopropyl-phenylamino)-4H-benzo[d][1,3]oxazin-6-yl]-2-(4-methyl-piperazin-1-yl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Methylpiperazin-1-yl)acetic acid | HCID 2762732 | — |
| Reactant | N2-(3-cyclopropyl-phenyl)-4H-benzo[d][1,3]oxazine-2,6-diamine | HCID 59231769 | — |
| Product | N-[2-(3-Cyclopropyl-phenylamino)-4H-benzo[d][1,3]oxazin-6-yl]-2-(4-methyl-piperazin-1-yl)-acetamide | HCID 59231905 | 25.1% |
Reaction Steps
Prepared from N2-(3-cyclopropyl-phenyl)-4H-benzo[d][1,3]oxazine-2,6-diamine (160 mg, 0.57 mmol) and and 4-methylpiperazin-1-acetic acid (109 mg, 0.69 mmol) according to the procedure described for example 93. Obtained the title compound as an off-white solid (60 mg, 25%), MS (ISP) m/e=420.3 [(M+H)+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163740B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-4442b6ca1a5d4e6eac3cf95dff5ad125 |
| Source note | uspto-grants-2012_04 |