Cyclopropanecarboxylic acid → HCID 178521735, compound

HRID 1695699Notes

Reaction equation

HRID 1695699 reaction equation
[CH:1]1([NH:9][C:10]2[O:11][CH2:12][C:13]3[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][C:14]=3[N:15]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:21]1([C:24](O)=[O:25])[CH2:23][CH2:22]1>>[CH:1]1([NH:9][C:10]2[O:11][CH2:12][C:13]3[CH:19]=[C:18]([NH:20][C:24]([CH:21]4[CH2:23][CH2:22]4)=[O:25])[CH:17]=[CH:16][C:14]=3[N:15]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 178507251HCID 178507251, compound

Product 1

HCID 178521735HCID 178521735, compoundYield 103.8%

Procedure

Prepared from N2-cyclooctyl-4H-benzo[d][1,3]oxazine-2,6-diamine (150 mg, 0.55 mmol) and and cyclopropane carboxylic acid (64 mg, 0.62 mmol) according to the procedure described for example 93. Obtained the title compound as a brown solid (195 mg, 99%), MS (ISP) m/e=342.2 [(M+H)+].

Sources & evidence

ORD record
ord-b77bdc91e7154b1fb8522925ec90b63a
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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