(4-Methylpiperazin-1-yl)acetic acid → HCID 178480913, compound

HRID 1695700Notes

Reaction equation

HRID 1695700 reaction equation
[CH:1]1([NH:9][C:10]2[O:11][CH2:12][C:13]3[CH:19]=[C:18]([NH2:20])[CH:17]=[CH:16][C:14]=3[N:15]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:21][N:22]1[CH2:27][CH2:26][N:25]([CH2:28][C:29](O)=[O:30])[CH2:24][CH2:23]1>>[CH:1]1([NH:9][C:10]2[O:11][CH2:12][C:13]3[CH:19]=[C:18]([NH:20][C:29](=[O:30])[CH2:28][N:25]4[CH2:26][CH2:27][N:22]([CH3:21])[CH2:23][CH2:24]4)[CH:17]=[CH:16][C:14]=3[N:15]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1

Participants

3

Reactant 2

HCID 2762732(4-Methylpiperazin-1-yl)acetic acidHCID 178507251HCID 178507251, compound

Product 1

HCID 178480913HCID 178480913, compoundYield 62%

Procedure

Prepared from N2-cyclooctyl-4H-benzo[d][1,3]oxazine-2,6-diamine (150 mg, 0.55 mmol) and and 4-methylpiperazin-1-acetic acid (95 mg, 0.60 mmol) according to the procedure described for example 93. Obtained the title compound as a brown solid (140 mg, 62%), MS (ISP) m/e=414.4 [(M+H)+].

Sources & evidence

ORD record
ord-05069202c41140e6ba014ead648c6e67
Source dataset
uspto-grants-2012_04
Patent number
US08163740B2

Reaction notes

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