Benzylamine → HCID 67278285, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (SR)-3-[benzenesulfonyl-((SR)-2-bromo-2-ethoxycarbonyl-ethyl)-amino]-2-bromo-propionic acid ethyl ester (CAS 58661-68-0) (13.8 g, 26.8 mmol) in toluene (54 ml) was added benzylamine (8.81 ml, 80.4 mmol) and the mixture was stirred at 90° C. for 1.5 h. Cooled to 23° C., filtered the solid off, washed with toluene and the filtrate was evaporated to leave a crude product which was purified by silica gel column chromatography with tert-butyl methyl ether and n-heptane 3:7 to give the title compound as light yellow crystals (7.0 g, 57%), MS (ISP) m/e=461.2 [(M+H)+].

Provenance & Evidence