o-Toluenesulfonyl chloride → HCID 86653305, compound

Participants

Reaction Steps

3-Amino-5-bromo-2-chloropyridine (767 mg) in dry pyridine (8 ml) was treated with 2-methylbenzenesulfonyl chloride (641 μl) then stirred at RT overnight. The reaction was purified by prep-HPLC. Desired fractions were combined, diluted with saturated sodium bicarbonate (aq) and brine and extracted into EtOAc. The solvent was dried over sodium sulfate and evaporated to give title compound (500 mg).

Provenance & Evidence