HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonyl chloride → N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonyl chloride | HCID 7369 | — |
| Reactant | 5-Bromo-2-ethoxypyridin-3-amine | HCID 53211699 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-[5-bromo-2-(ethyloxy)-3-pyridinyl]benzenesulfonamide | HCID 59860135 | — |
Reaction Steps
A solution of 5-bromo-2-(ethyloxy)-3-pyridinamine (1.45 g) in anhydrous pyridine (15 ml) was treated with benzenesulfonyl chloride (1.03 ml) then stirred at RT for 20 hr. The reaction was evaporated to dryness and the residue was purified by column chromatography on silica, eluting with 30% hexanes in DCM, to give the title compound (1.86 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163743B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-087614375e224ad2a79c1264e1426db0 |
| Source note | uspto-grants-2012_04 |