HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 44540218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-(Methylcarbamoyl)benzeneboronic acid | HCID 2773524 | — |
| Reactant | N-(6-Bromo-1H-indazol-4-yl)-2-pyridinecarboxamide | HCID 58255852 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 44540218 | HCID 44540218 | — |
Reaction Steps
N-(6-Bromo-1H-indazol-4-yl)-2-pyridinecarboxamide (100 mg, 0.31 mmol), {3-[(methylamino)carbonyl]phenyl}boronic acid (66 mg, 0.37 mmol), Pd(dppf)Cl2 (31 mg, 0.038 mmol) and 2 M sodium carbonate (aq) (0.468 ml, 0.936 mmol) in 1,4-dioxane (1.5 ml) and water (1 ml) were heated in a Biotage microwave at 150° C. for 30 mins. The reaction was purified by HPLC as follows to give title compound, 7 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163743B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-2a7faf98ed18413f869a98bee90ede37 |
| Source note | uspto-grants-2012_04 |