Hydrochloric Acid → N-(6-{6-Chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1H-indazol-4-yl)-6-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-2-pyridinecarboxamide

Participants

Reaction Conditions

Reaction Steps

6-(Chloromethyl)-N-[6-{6-chloro-5-[(methylsulfonyl)amino]-3-pyridinyl}-1-(phenylsulfonyl)-1H-indazol-4-yl]-2-pyridinecarboxamide (80 mg, 0.127 mmol) was dissolved in MeCN (1 ml). (2R,6S)-2,6-Dimethylmorpholine (16.05 mg, 0.139 mmol) was added followed by DIPEA (0.033 mL, 0.190 mmol) and then sodium iodide (18.99 mg, 0.127 mmol). The mixture was heated at 70° C. for 1 h, then the solvent was removed in vacuo to give an orange oil. IPA (1 ml) was added to the crude residue followed by aqueous NaOH (2M, 1 ml) and the solution was stirred at room temperature for 1 h. The solution was neutralised with 2M aqueous HCl and concentrated in vacuo. The residue was dissolved in DMSO (2 ml) and purified by MDAP (Method E). The resulting pale yellow gum was dissolved in DCM/MeOH (1:1) and added to the top of a 500 mg silica SPE cartridge. This was eluted with cyclohexane and the solvent was removed under a stream of nitrogen to give the title compound (2.2 mg).

Provenance & Evidence