Potassium Phosphate, Tribasic → HCID 58255779, compound

Participants

Reaction Conditions

Reaction Steps

N-(6-Bromo-1-methyl-1H-indazol-4-yl)-2-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-thiazole-4-carboxamide (50 mg, 0.108 mmol), 2,4-difluoro-N-[2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]benzenesulfonamide (46 mg, 0.108 mmol), Pd(dppf)Cl2 (16 mg, 0.022 mmol) and tripotassium phosphate (69 mg, 0.323 mmol) were added to 1,4-dioxane (1 ml) and water (0.25 ml) then put in the microwave. The reaction mixture was heated at 100° C. for 20 min. The solvent was blown down to give a brown oil which was dissolved in water (1 ml) and dioxane (1 ml), put in cardice for 15 min then put on freeze dryer to give a brown solid which was purified by MDAP (Method E) to give the title compound as a white solid (19 mg).

Provenance & Evidence