反应详情

N-{5-[4-Amino-1-(phenylsulfonyl)-1H-indazol-6-yl]-2-chloro-3-pyridinyl}methane sulfonamide (100 mg) was dissolved in DCM (5 ml) and pyridine (0.02 ml) was added. 2-Methyl-1,3-thiazole-4-carbonyl chloride (41 mg) was added and the reaction stirred at RT for 1 h. The reaction was evaporated to dryness and the residue was stirred in MeOH:2M NaOH (aq) (5 ml, 1:1, v/v) for 15 min. The reaction was neutralised with 2M HCl and evaporated to dryness. The residue was dissolved in DMSO (1 ml), filtered and purified by MDAP (method E). The pure fraction was evaporated to dryness to give title compound (33 mg).

1. customThe reaction was evaporated to dryness
2. stirringthe residue was stirred in MeOH
3. wait2M NaOH (aq) (5 ml, 1:1, v/v) for 15 min
4. customevaporated to dryness
5. dissolutionThe residue was dissolved in DMSO (1 ml)
6. filtrationfiltered
7. custompurified by MDAP (method E)
8. customThe pure fraction was evaporated to dryness